Hans Spemann's use of the concept double assurance, drawn from engineering models in cytology, is discussed in his work on lens development and the action of the organizer. His transformation of this concept within his neo-Lamarckian program is demonstrated and connected with the cultural factors which shaped engineering and embryology in Weimar Germany.

The presence of stigmatizing language in the electronic health record (EHR) has been used to measure implicit biases that underlie health inequities. The purpose of this study was to identify the presence of stigmatizing language in the clinical notes of pregnant people during the birth admission. We conducted a qualitative analysis on N = 1117 birth admission EHR notes from two urban hospitals in 2017. We identified stigmatizing language categories, such as Disapproval (39.3%), Questioning patient credibility (37.7%), Difficult patient (21.3%), (...) Stereotyping (1.6%), and Unilateral decisions (1.6%) in 61 notes (5.4%). We also defined a new stigmatizing language category indicating Power/privilege. This was present in 37 notes (3.3%) and signaled approval of social status, upholding a hierarchy of bias. The stigmatizing language was most frequently identified in birth admission triage notes (16%) and least frequently in social work initial assessments (13.7%). We found that clinicians from various disciplines recorded stigmatizing language in the medical records of birthing people. This language was used to question birthing people's credibility and convey disapproval of decision‐making abilities for themselves or their newborns. We reported a Power/privilege language bias in the inconsistent documentation of traits considered favorable for patient outcomes (e.g., employment status). Future work on stigmatizing language may inform tailored interventions to improve perinatal outcomes for all birthing people and their families. (shrink)

Starting from simple topological arguments due to Dirac on the classical rotational properties of extended rigid bodies, we abstract the concept of a finite-size spinor (FSS). The FSS is a concept distinct from both point spinors (e.g., electrons) and composite spinors (e.g., nuclei), and suggests a new model for baryons. The FSS offers a natural explanation of “threeness” for the quarks, excludes the existence of free quarks, denies the operational definition of quark spin statistics, and, moreover, leads to the dual (...) model of hadronic interactions. (shrink)

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Jelson Roberto de Oliveira, autor de “Compreender Hans Jonas”, é graduado em Filosofia pela Universidade Federal do Paraná, com especialização em Sociologia Política e mestrado em História da Filosofia Moderna e Contemporânea pela mesma universidade. Atualmente é professor da pós-graduação em Filosofia na PUC-PR, e coordenador do GT Hans Jonas, da Anpof, que reúne vários pesquisadores de nível nacional na área. Ética para a civilização tecnológica e A solidão como virtude moral em Nietzsche são alguns dos diversos títulos (...) que compõem o acervo de obras do autor. (shrink)

This article is the revised and annotated version of a lecture given at the German Historical Institute in London on 16 February 1982. I have discussed aspects of the same topic in other articles, e.g. ‘Wandel der Argumente für religiöse Toleranz und Glaubensfreiheit im 16. und 17. Jahrhundert’, in H. Lutz . Zur Geschichte der Toleranz und Religionsfreiheit , pp. 455–481, and ‘Parität, Neutralität und Toleranz’, to be published in Zwingliana 15.

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Biomedical ethics in the FRG is still in an embryonic stage. The Hippocratic tradition of paternalism is still dominant, general debates on Weltanschauungen have not yet been replaced by case-study methods and other means of resolving conflicts more effectively in pluralistic societies. Issues such as IVF and embryo research are predominantly treated in legal rather than in moral terms. Some new developments in moral assessment of prenatal care and care of the dying are reported. Allocational disputes over the future of (...) welfare-state health care systems are likely to continue without any major moral or political decision being reached. (shrink)

Mere exposure, generally, entails influences of familiarity manipulations on affective dependent variables. Previously (Phaf & Rotteveel, 2005), we have argued that familiarity corresponds intrinsically to positive affect, and have extended the correspondence to novelty and negative affect. Here, we present two experiments that show reverse effects of affective manipulations on perceived familiarity. In Experiment 1 affectively valenced exteroceptive cues of approach and avoidance (e.g., apparent movement) modulated recognition bias of neutral targets. This finding suggests that our correspondence hypotheses can be (...) generalised to an important aspect of emotion, namely approach and avoidance tendencies. In Experiment 2 participants? emotional mood was manipulated within the Jacoby?Whitehouse paradigm and a pattern of results was obtained as if consciousness was manipulated. We interpret the latter results within the affective modulation framework (AMF), which postulates facilitation of nonconscious processing by positive affect and an enhancement of conscious processing by negative affect. (shrink)

Asheim, O. Om handlingsformidling.--Hellesnes, J. Hending, handling og aktør.--Apel, K.-O. Vår tids konflikter og muligheten for en etiskpolitisk grunnorientering.--Böhler, D. Å kunne handle, å kunne forstå, å kunne tale.--Nordenstam, T. Vetenskaplig kompetens.--Måseide, A. Perspektivitet, intensjonalitet, refleksjon.--Øfsti, A. Moral og erscheinungswelt hos Kant.--Haga, Å. Transcendentalfilosofi og refleksiv argumentasjon.--Skirbekk, G. Folkelege tankar om sikt og oversikt.--Johannessen, K. S. Mening, kontekst, praksis og transcendentalitet.--Kalleberg, R. Fra kritikk av positivismen til kritikk av kapitalismens politiske økonomi.--Slagstad, R. Struktur-funksjonalisme og historisk materialisme.--Wyller, E. A. Politisk oppløsning (...) og forfall ifølge Platon.--Høibraaten, H. Romantisk eller teknologisk refleksjon. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Protestant Responses to Darwinism in Denmark, 1859–1914Hans Henrik HjermitslevFrom the 1870s onwards, Charles Darwin’s theory of evolution, published in On the Origin of Species (1859) and Descent of Man (1871), was an important topic among the followers of the influential Danish theologian N.F.S. Grundtvig (1783–1872). The Grundtvigians constituted a major faction within the Danish Evangelical-Lutheran Established Church, which included more than ninety percent of the population in the period (...) 1859–1914.This article demonstrates the influence of local contexts on the reception of scientific ideas by analyzing how specific aspects of Danish intellectual culture made the Grundtvigian reactions to Darwin’s theory different from Protestant denominations in America and Britain. Firstly, Grundtvig’s critique of Lutheran scriptural theology and his preference for the living word to the letters of the Bible legitimized liberal interpretations of Scripture. Secondly the philosophy of the Søren Kierkegaard protagonist, Rasmus Nielsen, made it possible for Grundtvigians to draw radical distinctions between science and faith. This specific “Danish Protestantism,” as the clergyman Frederik Jungersen phrased it in 1873, led the way for liberal Grundtvigians in coming to terms with Darwinism in the first decades of the twentieth century.1 [End Page 279]Protestant Responses to EvolutionIn recent decades historians have paid considerable attention to religious responses to Darwinism. Studies have revealed a variety of reactions to evolution depending on local contingencies, which has made it impossible to uphold any grand narrative of the dissemination of Darwinism.2 In his study of Calvinist attitudes toward Darwinism in Princeton, Belfast, and Edinburgh, David N. Livingstone thus emphasizes the importance of place in the reception of evolution.3 The historical complexities shaped by local contexts have been further demonstrated by scholars, who have explored the responses to Darwinism in a wide range of Protestant denominations in Britain and America.4 From the 1870s, when evolution was generally accepted among British and American scientists, liberal and even some orthodox theologians advocated various kinds of theistic evolutionism. It was not until the 1920s that creationists, who rejected evolution in general and human evolution in particular, took center stage in American Protestant answers to the Darwinian challenge. While many Protestant theologians in the decades around 1900 accepted that God had created the living world, including man, through evolution, very few embraced the specific Darwinian mechanism of natural selection that was often said to have atheistic implications. Instead liberal theologians, in line with many naturalists, often applied Lamarckian concepts of use-inheritance and teleological [End Page 280] development and prevalent ideas of progress that were seen as consistent with viewing evolution as a meaningful process and the unfolding of the Creator’s plan. According to James R. Moore, Peter J. Bowler, and Frederick Gregory this was the common way for liberal Christians to respond to organic evolution at least in the English-speaking world. It offered an acceptable compromise between science and faith. However, this article demonstrates that this strategy did not dominate in Denmark, where a separation model of science and faith was a more widespread approach when embracing the theory of evolution.5While studies by Jon H. Roberts and Ronald L. Numbers reveal considerable differences within the leading Protestant denominations such as Calvinists, Baptists, Lutherans, Episcopalians, and Methodists in their attitudes toward evolution, they detect no significant differences among the groups. Numbers notes however that “distinctive theological convictions sometimes influenced how people viewed Darwin’s theory.”6 This was especially the case when we move from the Protestant mainstream into distinctive groups such as the Seventh-day Adventists and the Pentecostals. In the case of the Adventists, their hyper-literalism and strong support for young-earth creationism owed much to the inspired writings of their founding prophetess Ellen G. White, while the relative indifference to evolution among Pentecostals can be explained by their Wesleyan-Methodist focus on religious experience over the study of Scripture.7 Likewise, in a study of attitudes toward evolution within the British Quaker community, Geoffrey Cantor has shown how discussions of Darwinism between evangelicals and moderates centred on the relative importance that should be paid to the Bible versus the doctrine of the Inner Light. Emphasizing... (shrink)

Die vorliegende Arbeit besteht, von Beigaben wie Indizes und Bibliographie abgesehen, aus einer 124 Seiten umfassenden Einleitung und einer 328 Seiten umfassenden vollständigen Werkausgabe des bisher wenig bekannten Antipalamiten Theodoros Dexios. Seine Schriften, eine von POLEMIS (P.) als „Appellatio“ bezeichnete Beschwerde über die Voreingenommenheit des Ioannes Kantakuzenos auf dem Konzil von 1351, zwei Briefe und ein von P. so genannter „Tractatus brevis de Christo ipso splendente in Transfiguratione“ sind anonym überliefert, zudem auch ohne Überschriften. Zu Beginn der Einleitung wird G. (...) MERCATIs Annahme, daß die Schriften von Dexios verfaßt wurden, gegen J. MEYENDORFF, der sie dem Arsenios von Tyros zuwies, überzeugend verteidigt. Der Autor des 1. Briefes vertrat die merkwürdige Meinung, daß das Thaborlicht mit dem menschlichen Körper Christi identisch gewesen sei (XVI). Diese Ansicht kritisierte Isaak Argyros in seinem Brief an Gedeon unter Namensnennung des Dexios, wie Mercati bereits feststellte (XXIII f.). Daß die genannten Schriften, die teils in Vat. Gr. 1111, teils in Vat. Gr. 1823 überliefert sind (XIII), auf denselben Autor zurückgehen, ist daraus zu erschließen, daß der Schreiber von Vat. Gr. 1823 in Vat. Gr. 1111 Autorenkorrekturen vornahm (XV f.). Ein wichtiger Punkt der Widerlegung Meyendorffs besteht auch darin, daß dieser die Worte des Dexios, die sich auf den Schluß des vom „seligen Gregoras“ inspirierten Glaubensbekenntnisses der Antipalamiten im Jahr 1351 beziehen, nämlich „an letzter Stelle war in ihm (dem Bekenntnis) folgendes zu lesen: ‚Hinsichtlich des Kalabrers Barlaam und des Akindynos sagen wir, daß wir damit einverstanden sind, was die heilige Kirche Gottes entschieden und festgelegt hat‘ (220), indem wir auf unseren Patriarchen verwiesen“, auf Ignatios von Antiochien, den Vorgesetzten des Arsenios, bezog, dieser schmähliche, wenn auch wohl postume Verrat an Akindynos (so unsere Meinung) aber laut P. eine Anerkennung des Tomos von 1341 bedeutet, mit dem Patriarchen demnach Kalekas gemeint ist (XX f.). P. weist nach, daß der Brief des Dexios, auf den sich Argyros in seinem Brief an Gedeon bezieht, trotz gleicher Thematik nicht mit dem von ihm herausgegeben Brief I identisch ist, sondern etwas früher (XXVI versehentlich „later“) geschrieben wurde (XXVI–XXVIII). Die Datierung der „Appellatio“ auf die Zeit zwischen 1351 und 1354 (Sturz des Kantakuzenos) ist sicherlich richtig. Da Gregoras in seinen zweiten „Antirrhetikoi“ wie Dexios von der Nichtveröffentlichung des Tomos von 1351, der Unvollständigkeit der erworbenen Abschrift wie auch von der Gefahr spricht, durch den Herrscher ermordet zu werden (s. JÖB 36, 1986, 263 f. 276), ist laut meiner Datierung (s. JÖB 27, 1978, 146, Nr. 70) 1353 als wahrscheinliches Datum der Abfassung anzusehen. P. verfaßte eine bemerkenswerte Anmerkung zu Georgios von Pelagonia (XXXI f., A. 65). Die Identifizierung des Georgios Gabrielopulos mit Georgios, dem Philosophen, geht auf R.-J. LOENERTZ und F. TINNEFELD zurück, die mögliche Identifizierung des Georgios von Pelagonia mit Gabrielopulos auf mich (s. PLP II, Nr. 3433 und Talbot in ODB II 838 f., die PLP ausschreibt). Inzwischen bin ich zu dem Schluß gekommen, daß Georgios von Pelagonia, der an Akindynos Kritik übt, auf Grund seiner guten Informiertheit kein anderer sein kann als Akindynos, der wegen seiner Voreingenommenheit gegen Barlaam im Jahr 1341 Selbstkritik übt. Akindynos stammte aus der Region von Pelagonia. Möglicherweise ist er nach seiner Flucht aus Konstantinopel 1347 mit Hilfe Stefan Dušans sogar Bischof von Pelagonia geworden. (shrink)

Unitary field theories and “SUPER-GUT” theories work with an universal continuum, the structured spacetime of R. Descartes, B. Spinoza, B. Riemann, and A. Einstein, or a (Machian (1–3) ) structured vacuum according the quantum theory of unitary fields (Dirac, (4,5) and Heisenberg (6–8) ). The atomistic aspect of the substantial world is represented by the fundamental constants which are invariant against “all transformations” and which “depend on nothings” (Planck (9–11) ). A satisfactory unitary theory has to involve these constants like (...) the mathematical numbers. Today, Planck's conception of the three elementary constants ħ, c, and G may be the key to general relativistic quantum field theory like unitary theory. However, the elementary constants are a question of measurement-theory, also.According to Popper's theory (12–16) of induction, such unitary theories are “universal explaining theories.” The fundamental constants involve the complementarity between the universal statements in unitary theory and the “basic statements” in the language of classical observables. (shrink)

Constructibility and complexity play central roles in recent research in computer science, mathematics and physics. For example, scientists are investigating the complexity of computer programs, constructive proofs in mathematics and the randomness of physical processes. But there are different approaches to the explication of these concepts. This volume presents important research on the state of this discussion, especially as it refers to quantum mechanics. This `foundational debate' in computer science, mathematics and physics was already fully developed in 1930 in the (...) Vienna Circle. A special section is devoted to its real founder Hans Hahn, referring to his contribution to the history and philosophy of science. The documentation section presents articles on the early Philipp Frank and on the Vienna Circle in exile. Reviews cover important recent literature on logical empiricism and related topics. (shrink)

Kann ein Werk, das vor allem Handbuch zu den Vorlesungen sein sollte, mit seinen Kurzfassungen von Logik und Phanomenologie die in den entsprechenden Buchern vorgelegten Entwurfe uberhaupt adaquat wiedergeben? Wie sind die Veranderungen bezuglich der Einleitungsfunktion der Phanomenologie zu bewerten? Wie schliesslich sind die auch sonst nur in Vorlesungsmitschriften uberlieferten Systemteile zur Philosophie der Natur und zur Philosophie des Geistes im Gesamtzusammenhang des Systems zu deuten? - Dies sind nur einige der Fragen, die der vorliegende Band aufgreift, um gleichzeitig eine (...) umfassende Einfuhrung in die Probleme des Hegel'schen Systems bzw. seiner einzelnen Teile zu liefern. Mit Beitragen von H.-Ch. Lucas, J. D'Hondt, N. Waszek, O. Poggeler, U. Rameil, G. Baptist, M. Bykova, W. Bonsiepen, R. Wahsner, M. Bienenstock, F. Hespe, B. Tuschling, A. Th. Peperzak, H. Schneider, M. Alvarez-Gomez, K. J. Schmidt, K. Dusing, A. Nuzzo und H. F. Fulda. (shrink)

That the story of Cupid and Psyche in Apuleius' Metamorphoses is a version of a common world-wide folk-tale has long been recognized. Scholarly debate has concentrated on the conclusions to be drawn from this with regard to the significance of the story—mythological, religious, allegorical, and so on. With the additional information provided by Swahn's comprehensive monograph on the subject an attempt can now be made to study some of the aspects of literary technique involved in the adaptation of the folk-tale. (...) In what follows I have tried to avoid making any assumptions about a possible literary source of Apuleius' tale. I am concerned with the ways in which the literary version which we possess modifies the folk material, and not with the author of this modification. (shrink)

Some of the authors of the essays on Chinese philosophers prefer the pin yin system of romanization for Chinese names and words, while others prefer the Wade‐Giles system. Given that both systems are in wide use today, important names and words are given in both their pin yin and Wade‐Giles formulations. The author's preference is printed first, followed by the alternative romanization within brackets.

The centerpiece of Jeffrey Bub's book Interpreting the Quantum World is a theorem (Bub and Clifton 1996) which correlates each member of a large class of no-collapse interpretations with some 'privileged observable'. In particular, the Bub-Clifton theorem determines the unique maximal sublattice L(R,e) of propositions such that (a) elements of L(R,e) can be simultaneously determinate in state e, (b) L(R,e) contains the spectral projections of the privileged observable R, and (c) L(R,e) is picked out by R and e alone. In (...) this paper, we explore the issue of maximal determinate sets of observables using the tools provided by the algebraic approach to quantum theory; and we call the resulting algebras of determinate observables, "maximal *beable* subalgebras". The capstone of our exploration is a generalized version of Bub and Clifton's theorem that applies to arbitrary (i.e., both mixed and pure) quantum states, to Hilbert spaces of arbitrary (i.e., both finite and infinite) dimension, and to arbitrary observables (including those with a continuous spectrum). Moreover, in the special case covered by the original Bub-Clifton theorem, our theorem reproduces their result under strictly weaker assumptions. This added level of generality permits us to treat several topics that were beyond the reach of the original Bub-Clifton result. In particular: (a) We show explicitly that a (non-dynamical) version of the Bohm theory can be obtained by granting privileged status to the position observable. (b) We show that Clifton's (1995) characterization of the Kochen-Dieks modal interpretation is a corollary of our theorem in the special case when the density operator is taken as the privileged observable. (c) We show that the 'uniqueness' demonstrated by Bub and Clifton is only guaranteed in certain special cases -- viz., when the quantum state is pure, or if the privileged observable is compatible with the density operator. We also use our results to articulate a solid mathematical foundation for certain tenets of the orthodox Copenhagen interpretation of quantum theory. For example, the uncertainty principle asserts that there are strict limits on the precision with which we can know, simultaneously, the position and momentum of a quantum-mechanical particle. However, the Copenhagen interpretation of this fact is not simply that a precision momentum measurement necessarily and uncontrollably disturbs the value of position, and vice-versa; but that position and momentum can never in reality be thought of as simultaneously determinate. We provide warrant for this stronger 'indeterminacy principle' by showing that there is no quantum state that assigns a sharp value to both position and momentum; and, a fortiori, that it is mathematically impossible to construct a beable algebra that contains both the position observable and the momentum observable. We also prove a generalized version of the Bub-Clifton theorem that applies to "singular" states (i.e., states that arise from non-countably-additive probability measures, such as Dirac delta functions). This result allows us to provide a mathematically rigorous reconstruction of Bohr's response to the original EPR argument -- which makes use of a singular state. In particular, we show that if the position of the first particle is privileged (e.g., as Bohr would do in a position measuring context), the position of the second particle acquires a definite value by virtue of lying in the corresponding maximal beable subalgebra. But then (by the indeterminacy principle) the momentum of the second particle is not a beable; and EPR's argument for the simultaneous reality of both position and momentum is undercut. (shrink)

The thesis that all learning has the character of enquiry is advanced and its implications are explored. R. G. Collingwood's account of ‘the logical priority of the question’ is explained and Hans-Georg Gadamer's hermeneutical justification and development, particularly the rejection of the re-enactment thesis, is discussed. Educators are encouraged to consider the following implications of the character of the question implied in all learning: (i) that it is a question that is constituted in the event rather than prepared or (...) given in advance, and that this leads to a necessary tension between learning and the curriculum or scheme, (ii) that it is a question that concerns some subject matter or issue that is at stake for both the student and the object of study, which draws our attention to the ‘intentionality’ of learning, and (iii) that it is a question that operates on the level of being—students are ‘called into question’, and thus transformed, by the object of study. (shrink)